Acting Irrespective of Hope

The hope and reality of long-acting hemophilia products.

Recombinant DNA technology and protein engineering are creating hope that we can address ongoing challenges in hemophilia care such as reducing the costs of therapy, increasing the availability to the developing world, and improving the functional properties of these proteins. Technological advances to improve the half-life of recombinant clotting factors have brought long-acting clotting facto...

RNA localization in Xenopus oocytes uses a core group of trans-acting factors irrespective of destination.

The 3' untranslated region of mRNA encoding PHAX, a phosphoprotein required for nuclear export of U-type snRNAs, contains cis-acting sequence motifs E2 and VM1 that are required for localization of RNAs to the vegetal hemisphere of Xenopus oocytes. However, we have found that PHAX mRNA is transported to the opposite, animal, hemisphere. A set of proteins that cross-link to the localization elem...

Hope against Hope

In the penultimate chapter of the Bible, in the opening statement of the very last speech God makes in the whole of the Christian Scriptures, God says: "Behold I am making all things new" (Rev 21:5). The prophet sees the old heavens and the old earth the universe as it now is passing away, and new heavens and a new earth, God's new creation of all things, coming into being. It is not that God r...

"Hope, Danger's Comforter": Thucydides, Hope, Politics

Effect of hope therapy on the hope of diabetic patients

BACKGROUND Hope is the most important factor in diabetic patients' life. The level of hope may be changing among these individuals as a result of chronic nature of diabetes and its complications. When the level of hope increases among these patients, they can resist against physical and psychological complications of diabetes more, accept the treatment better, enjoy life more, and adapt with th...